They replace suspended captain Matthew Pavlich and Hayden Ballantyne, who has a hamstring injury.
The emergencies for fifth-placed Freo’s match against the sixth-placed Tigers will be Matt Taberner, Jack Hannath and Jesse Crichton.
Duffield injured a calf in the game against Geelong at Simonds Stadium and was subbed out.
He missed the next two games against St Kilda and West Coast but returns to slot straight back into a defence that has conceded the fewest points in the AFL this season.
The small Neale is a like-for-like replacement for Hayden Ballantyne.
He has been injured for a chunk of this season but has returned to play well at WAFL level.
