Clancee Pearce, Zac Clarke, Matt Taberner and Zac Dawson are also into the team for the Patersons Stadium clash.
Fremantle Injury List
They replace the injured Chris Mayne, Michael Walters and Garrick Ibbotson, while Tom Sheridan and Jack Hannath were listed as emergencies along with Melbourne recruit Colin Sylvia.
Dawson was an automatic inclusion after serving his one-match suspension for tripping.
Pearce performed strongly to gather 39 disposals at WAFL level last weekend, while Clarke was also among Peel's best.
WAFL Watch: Round 3
Key forward Taberner made four appearances in his debut 2013 season, kicking two goals.
Simpson, who the club took with pick 16 in the 2012 National Draft, made his debut in round 23 last season in a game that saw a host of regulars rested ahead of the finals.
The 20-year-old midfielder has been in strong form at WAFL level for the Thunder this season, showcasing a solid defensive game to complement his undoubted skills.
