The odds are against Connor Blakely earning an immediate call-up to Fremantle's winning outfit, but mobile forward Cam McCarthy is a strong chance to return for Saturday night's marquee clash with the Western Bulldogs.
Blakely hasn’t played in 2019 after suffering a hamstring injury in January.
The strong-bodied 23-year-old has been pushing hard at training to get straight back into the line-up but is unlikely to be recalled for David Mundy's 300th game.
"When you're winning it means people are in form, it's a very tough spot to get into," Lyon said.
"It's more unlikely than likely, but he's conditioned to be able to play if we need him."
McCarthy needs to train later this week to put his hand up after missing the uplifting 24-point win over his former club Greater Western Sydney due to a virus.
His potential comeback could force a reshuffle, with Brennan Cox a candidate to move back to defence to cover for suspended Taylin Duman.
"It's disappointing to lose Taylin, he learns a lesson," Lyon said.
Cox went scoreless coming into the line-up for McCarthy but was part of a potent forward mix which topped the ton for the second time this season in Canberra.
"I thought the midfield gave plenty of supply and our forwards capitalised on it, and I thought Cox played a part in that," Lyon said.
"It's about kicking goals and seeing goals kicked, so he helped see goals kicked."
Amid criticism about Optus Stadium's firm surface, Lyon said Fremantle have had concerns in the past but believed there were "lots of threads" that caused injuries.
"Certainly we suffered some injuries (last year), plantar fascia, not too dissimilar, a couple of similar incidents," Lyon said.
"So I understand the frustration. Fortunately this year we've had a good run with it and we hope that run continues.”