Fremantle has lost its first Carlton Draught Derby since 2012, after a 24-point loss to West Coast on Sunday at Domain Stadium.

The Eagles started brightly with the first six goals and kept Freo at bay to seal the 15.14 (104) to 11.14 (80) victory.

The win keeps West Coast two points ahead of Hawthorn in the race for second spot and the all-important home final.

But it may have come at a cost with another injury to a key defender with Will Schofield subbed off during the third term with a hamstring issue.

Fremantle defender Alex Silvagni faces the prospect of missing the start of the finals after being reported for a crude elbow on Jamie Cripps midway through the second quarter.Cripps was left with an injured jaw after copping the swinging elbow from Silvagni in an incident that occurred 80m off the ball.

The young Eagles forward was clearly distressed while being assessed on the bench, but he managed to return in the third quarter.

West Coast defender Will Schofield might also be set for a stint on the sidelines after being subbed out with a hamstring injury in the third term.

Sunday's result means West Coast edges ahead 22-20 in the Carlton Draught Derby ledger, but more importantly it puts the club in the box seat to nail down second spot.

The Eagles will seal second spot if they beat the Bulldogs (home), Adelaide (away), and St Kilda (home) in the final three rounds.

Fremantle is still likely to win the minor premiership despite the slip-up.

The Freo Dockers dominated the second half on the back of Nat Fyfe's brilliance and Aaron Sandilands' ruck dominance.

But the Eagles managed to snare enough goals against the run of play to secure an overdue victory against their arch rivals.

West Coast was keen to make a fast start to the match after conceding the first 11 goals in their round three Derby loss.

And their wishes were answered as key forwards Josh Kennedy and Jack Darling weaved their magic early.

The star spearheads pulled down a series of big marks and kicked one goal each to give West Coast a 44-9 edge at the first break.

Fyfe tallied just two disposals in the opening quarter, but the Brownlow medal favourite shot to prominence in the second half as he, David Mundy, and Sandilands willed their side into the match.

Fremantle closed the margin from 41 points down to 17 late in the match.

But a late goal to Darling sealed the deal in front of 41,959 fans.

FREMANTLE          1.3   2.6    5.10    11.14   (80)                  
WEST COAST        7.2   8.7    11.12   15.14   (104)          

GOALS
Fremantle: Walters 4, Pavlich 2, Mundy, Mayne, Sheridan, Griffin, Hill
West Coast: Hill 4, Kennedy 2, Darling 2, Hutchings, Shuey, Lycett, Yeo, Rosa, Sinclair, McGinnity

BEST
Fremantle: Hill, Sandilands, Mundy, Fyfe, Walters, Sheridan
West Coast: Hill, Gaff, Sheppard, Hurn, Rosa, Hutchings, Priddis

INJURIES
Fremantle: Nil
West Coast: Schofield (left hamstring)

SUBSTITUTES
Fremantle: Hayden Crozier replaced Michael Barlow in the third quarter
West Coast: Patrick McGinnity replaced Will Schofield in the third quarter

Reports: Alex Silvagni (Fremantle) for striking Jamie Cripps (West Coast) in the second quarter

Umpires: Dalgleish, Ryan, Jeffery

Official crowd: 41,959 at Domain Stadium