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Brianna Green will miss Saturday's game against Collingwood at Optus stadium after injuring herself at training on Thursday night.
The midfielder had a limited season last year after injuring her collarbone in round two against Brisbane and did not play for the rest of 2017.
Lara Filocamo will replace the injured Green who will have scans later today on her injured knee.
Lisa Webb will also make her debut for Fremantle, while Gemma Houghton will play her first game in purple for 2018 after missing last week's opening round against the Bulldogs.
Final team for round two clash between Fremantle v Collingwood
Fremantle will take on Collingwood at 4.10pm on Saturday 10 February at Optus Stadium